Substituted pteridinones, pyrimidines, pyrrolopyrimidines, and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors: Pharmacophore modeling data

yuza blonde The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway that is aberrantly active in a range of cancer types and has been recognized an anticancer target.The inhibition of RSK2 kinase activity would disrupt multiple pro-cancer processes; however, there are few RSK2 inhibitors.The data have been obtained for a series of p

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Research on optimization of temperature sensitive points of machine tool thermal error based on independent variable selection criteria

Abstract In order to improve the prediction accuracy and robustness of the machine tool thermal error model, a method to select temperature sensitive points of fender two tone amp the machine tool thermal error model based on independent variable selection criteria is proposed.Firstly, the positioning error of the machine tool is divided into geome

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A New Method for Reconstructing Data Considering the Factor of Selected Provider Nodes Set in Distributed Storage System

In the distributed storage system, when data need to be recovered after node failure, the erasure code redundancy method occupies less storage space than the multi-copy berkley power worm 100 pack method.At present, the repair mechanism using erasure code to reconstruct the failed node only considers the improvement of link bandwidth on the repair

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Introduction of novel intravascular ultrasound preceding with angled guiding catheter (I-PAD) technique to treat chronic total occlusions in peripheral artery disease

Abstract Background The optimal endovascular treatment (EVT) for chronic total occlusion (CTO) lesions in patients with peripheral artery disease (PAD) has remained unestablished.We encountered a patient with PAD in whom CTO was successfully treated using a novel technique that involved intravascular ultrasound (IVUS) and angled guiding catheter: I

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